Therapeutics targeting the fibrinolytic system
نویسندگان
چکیده
منابع مشابه
Natural Therapeutics Targeting Survivin
Volume 1 • Issue 6 • 1000e121 Biochem Anal Biochem ISSN:2161-1009 Biochem, an open access journal An interesting study analysing the effect of curcumin on hepatocellular carcinoma cells revealed the decreased efficacy of curcumin treatment on cells when survivin is suppressed. Using siRNA methods, survivin was suppressed in HCC cells and curcumin was tested for its anticancer effects. Interesti...
متن کاملTargeting microenvironment in cancer therapeutics
During development of a novel treatment for cancer patients, the tumor microenvironment and its interaction with the tumor cells must be considered. Aspects such as the extracellular matrix (ECM), the epithelial-mesenchymal transition (EMT), secreted factors, cancer-associated fibroblasts (CAFs), the host immune response, and tumor-associated microphages (TAM) are critical for cancer progressio...
متن کاملThe fibrinolytic system in pre-eclampsia.
Plasma fibrinolytic activity and plasma inhibitory activity against urokinase and tissue activator were measured in primigravidae with moderate or severe pre-eclampsia and in gestation-matched primigravidae with uncomplicated pregnancy. The mean levels of fibrinolytic activity and inhibitory activity against urokinase and tissue activator did not differ significantly between the pre-eclampsia a...
متن کاملDisorders of the blood coagulation-fibrinolytic system
Most human cells have no direct contact with the external environment and their living conditions are ensured by blood. An essential criterion for normal blood circulation is the ability of the blood to arrest bleeding at sites of tissue injury and to prevent thrombus formation inside the blood vessels under normal conditions. The balance between these two extreme states is rigorously controlle...
متن کاملNutritional influences on the fibrinolytic system.
Fibrinolytic system In addition to the mechanisms which achieve haemostasis by the formation of fibrin-stabilized platelet plugs, man possesses an efficient system designed to remove unwanted or excessive fibrin. The enzyme which cleaves fibrin into soluble degradation products is termed plasmin (EC 3.4.4.14); it is present in the circulation as a zymogen known as plasminogen. The activation of...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Experimental & Molecular Medicine
سال: 2020
ISSN: 1226-3613,2092-6413
DOI: 10.1038/s12276-020-0397-x